olig2-expressing hindbrain cells are required for migrating facial motor neurons
نویسندگان
چکیده
منابع مشابه
Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain.
During development, a specific subset of ventral spinal cord precursors called pMN cells produces first motor neurons and then oligodendrocyte progenitor cells (OPCs), which migrate, divide and differentiate as myelinating oligodendrocytes. pMN cells express the Olig2 transcription factor and Olig2 function is necessary for formation of spinal motor neurons and OPCs. In the hindbrain and midbra...
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Migration of neurons from their birthplace to their final target area is a crucial step in brain development. Here, we show that expression of the off-limits/frizzled3a (olt/fz3a) and off-road/celsr2 (ord/celsr2) genes in neuroepithelial cells maintains the facial (nVII) motor neurons near the pial surface during their caudal migration in the zebrafish hindbrain. In the absence of olt/fz3a expr...
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In vitro studies have provided evidence that beta1 integrins in motor neurons promote neurite outgrowth, whereas beta1 integrins in myotubes regulate acetylcholine receptor (AChR) clustering. Surprisingly, using genetic studies in mice, we show here that motor axon outgrowth and neuromuscular junction (NMJ) formation in large part are unaffected when the integrin beta1 gene (Itgb1) is inactivat...
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Politicians, pundits, and even your best friends occasionally do things that make you wonder how their brains are wired. The next time you have that thought, consider consulting a developmental neuroscientist: they work every day to understand the processes that wire up everyone’s brains. It’s a mind-boggling job, because as an embryo develops, the connections within its brain ramify, becoming ...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2012
ISSN: 1058-8388
DOI: 10.1002/dvdy.23718